The Week 5 Opening Lines have been set and are ready to be picked apart. The only line that is off the board at the current moment is the Chicago-Carolina game due to Jay Cutler's concussion and Steve Smith's injured ankle.

The 49ers have already moved from 3-point favorites over Philadelphia next Sunday night to 3.5-point favorites.

In addition, the Bills went from 1-point favorites over Jacksonville to 1-point underdogs.